治疗性血浆置换在儿童神经免疫性疾病中的疗效与安全性：一项单中心小型研究
Efficacy and Safety of Therapeutic Plasma Exchange in Children with Neuroimmunological Disorders: A Limited Unicentral Study.
作者信息
Nikkhah Ali, Nasehi Mohammad Mahdi, Momtazmanesh Nader, Etemad Kourosh, Hajatnia Somayeh
机构信息
Pediatric Neurology Research Center, Research Institute for Children's Health, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pediatric Neurology Department, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Child Neurol. 2024 Spring;18(2):31-41. doi: 10.22037/ijcn.v18i1.40139. Epub 2024 Mar 12.
OBJECTIVES
Therapeutic plasma exchange (TPE) is a plasmapheresis procedure whose Safety data for pediatric neuro-immunological disorders (PNID) is confined. The present research documents TPE's safety and feasibility data in these conditions.
MATERIALS & METHODS: The current study involved six distinct groups of patients with PNID undergoing TPE: neuromyelitis optic spectrum disorder (NMOSD), autoimmune encephalitis (AIE), acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), Guillain-Barre syndrome (GBS), and optic neuritis (ON). This study documented complications related to each TPE process. In addition, TPE's efficacy was studied in these patients.
RESULTS
The present study recorded adverse effects in 18 patients with PNID that received 121 TPE cycles: five cycles (4.13%) in MS, three (2.48%) in AIE subgroup, one (0.82%) in ADEM, and two (1.65%) in GBS. No severe complications were observed among the patients.
CONCLUSION
Patients with PNID tolerated therapeutic plasma exchange, which was a safe process.
目的
治疗性血浆置换（TPE）是一种血浆置换程序，其关于儿童神经免疫性疾病（PNID）的安全性数据有限。本研究记录了TPE在这些情况下的安全性和可行性数据。
材料与方法
本研究纳入了六组接受TPE的不同PNID患者：视神经脊髓炎谱系障碍（NMOSD）、自身免疫性脑炎（AIE）、急性播散性脑脊髓炎（ADEM）、多发性硬化症（MS）、吉兰 - 巴雷综合征（GBS）和视神经炎（ON）。本研究记录了与每个TPE过程相关的并发症。此外，还研究了TPE在这些患者中的疗效。
结果
本研究记录了18例接受121个TPE疗程的PNID患者出现的不良反应：MS患者中有5个疗程（4.13%），AIE亚组中有3个疗程（2.48%），ADEM患者中有1个疗程（0.82%），GBS患者中有2个疗程（1.65%）。患者中未观察到严重并发症。
结论
PNID患者耐受治疗性血浆置换，这是一个安全的过程。
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