De Tito Stefano, Hervás Javier H, van Vliet Alexander R, Tooze Sharon A
The Molecular Cell Biology of Autophagy, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
The Molecular Cell Biology of Autophagy, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Instituto Biofisika (CSIC, UPV/EHU), Departamento de Bioquímica y Biología Molecular, Universidad del País Vasco, Bilbao, Spain.
Trends Biochem Sci. 2020 Jun;45(6):484-496. doi: 10.1016/j.tibs.2020.03.010. Epub 2020 Apr 16.
Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles underlying the autophagy process, be it as signaling platforms or through the contribution of proteins and lipids. The Golgi complex is recognized as being a central transport hub in the cell, with a critical role in endocytic trafficking and endoplasmic reticulum (ER) to plasma membrane (PM) transport. However, the Golgi is also an important site of key autophagy regulators, including the protein autophagy-related (ATG)-9A and the lipid, phosphatidylinositol-4-phosphate [PI(4)P]. In this review, we highlight the central function of this organelle in autophagy as a transport hub supplying various components of autophagosome formation.
传统上，自噬被描绘为一个信号级联反应，最终形成一个降解细胞内物质的自噬体。然而，最近的研究已经确定了自噬过程背后的无数途径和细胞器，无论是作为信号平台还是通过蛋白质和脂质的作用。高尔基体被认为是细胞中的一个中央运输枢纽，在内吞运输以及从内质网（ER）到质膜（PM）的运输中起关键作用。然而，高尔基体也是关键自噬调节因子的重要位点，包括蛋白质自噬相关蛋白（ATG）-9A和脂质磷脂酰肌醇-4-磷酸[PI(4)P]。在这篇综述中，我们强调了这个细胞器在自噬中的核心功能，即作为一个提供自噬体形成各种成分的运输枢纽。
