Domenzain M E, Shapiro A G, Bezjian A A, LeMaire W J
Fertil Steril. 1977 May;28(5):531-4. doi: 10.1016/s0015-0282(16)42552-5.
Luteinizing hormone-releasing hormone (LHRH) (100 microng) was administered subcutaneously to healthy female volunteers 2 and 4 weeks after induced abortion in the first trimester (group A) and the midtrimester (group B). Four patients were studied in each group. The response to LHRH was determined in terms of plasma LH and follicle-stimulating hormone levels. Adequate pituitary response occurred in subjects of group A at both 2 and 4 weeks. In group B pituitary unresponsiveness was found at 2 weeks which persisted to some extent at 4 weeks. These data are in accord with the pituitary unresponsiveness observed after termination of pregnancy at term and suggest that the duration of pregnancy has an influence on the development of this unresponsiveness.
在妊娠早期（A组）和妊娠中期（B组）人工流产后2周和4周，对健康女性志愿者皮下注射促黄体生成激素释放激素（LHRH，100微克）。每组研究4例患者。根据血浆促黄体生成素（LH）和促卵泡生成素水平确定对LHRH的反应。A组受试者在2周和4周时垂体均有充分反应。B组在2周时发现垂体无反应，4周时仍有一定程度的无反应。这些数据与足月妊娠终止后观察到的垂体无反应一致，提示妊娠期长短对这种无反应的发生有影响。
