Moss R L, McCann S M
Neuroendocrinology. 1975;17(4):309-18. doi: 10.1159/000122369.
In order to evaluate the precise role of luteinizing hormone-releasing factor (LRF) in mediating the onset of sexual behavior, the specificity, time-course, and dose-response relationship of LRF-facilitated lordosis behavior were determined. Ovariectomized female rats, pretreated with estrone and LRF, displayed a pattern of lordosis behavior which differed little from that produced by estrone-progesterone. Little if any lordosis behavior was observed in response to LRF alone, estrone alone, or estrone in combination with luteinizing hormone (LH), follicle-stimulating hormone (FSH), or thyrotropin-releasing factor (TRF). Furthermore, LRF-induced lordosis behavior occurred in the absence of the adrenals, thus eliminating adrenal progesterone as a factor in facilitating the appearnce of lordosis behavior. The LRF-facilitated lordosis behavior was seen 2 h after the injection of LRF and was maintained for a total of 8 h. A minimal dose of 150 ng LRF was required to initiate the first consistent appearance of lordosis behavior; the maximum response was obtained with 500 ng. It is thus suggested that LRF is not only responsible for the ovulatory discharge of LH and subsequent ovulation, but may also play a role in the initiation of the onset of mating behavior in the female rat.
为了评估促黄体生成激素释放因子（LRF）在介导性行为启动过程中的精确作用，我们确定了LRF促进脊柱前凸行为的特异性、时间进程和剂量反应关系。用雌酮和LRF预处理的去卵巢雌性大鼠表现出的脊柱前凸行为模式，与雌酮 - 孕酮所产生的模式几乎没有差异。单独给予LRF、单独给予雌酮或雌酮与促黄体生成素（LH）、促卵泡激素（FSH）或促甲状腺激素释放因子（TRF）联合使用时，几乎未观察到脊柱前凸行为。此外，LRF诱导的脊柱前凸行为在没有肾上腺的情况下也会发生，从而排除了肾上腺孕酮作为促进脊柱前凸行为出现的一个因素。在注射LRF后2小时出现LRF促进的脊柱前凸行为，并总共持续8小时。启动首次持续出现脊柱前凸行为所需的最小剂量为150 ng LRF；500 ng时获得最大反应。因此表明，LRF不仅负责LH的排卵释放和随后的排卵，还可能在雌性大鼠交配行为启动的开始阶段发挥作用。
