Klimov P K, Polosatov M V
Fiziol Zh SSSR Im I M Sechenova. 1977;63(2):313-9.
With the aid of affinic, ion-exchange- and gel-chromatography, disc- and immunoelectrophoresis, the blood serum of healthy people and animals was shown to contain proteins capable of interaction with gastrin. These proteins form a system including, along with albumins, globulins with electrophoretic mobility of alpha- and gamma-globulins. The immunoglobulins interacting with gastrin are related to the G class. Presence of a number of forms of the labile, spatially organized structural hormonal protein complexes is suggested, which play the functional part of an effective storage and transport of the hormone from the hormone-producing cell to the effector one, and excitation of its membrane's structures. Such overmolecular complexes seem to be easier recognized by the celleffector and to exert a specific action.
借助亲和色谱、离子交换色谱和凝胶色谱、圆盘电泳和免疫电泳，已证实在健康人和动物的血清中含有能够与胃泌素相互作用的蛋白质。这些蛋白质形成一个系统，除白蛋白外，还包括具有α-球蛋白和γ-球蛋白电泳迁移率的球蛋白。与胃泌素相互作用的免疫球蛋白属于G类。有人提出存在多种不稳定的、空间组织化的结构激素蛋白复合物形式，它们在激素从产生激素的细胞到效应细胞的有效储存和运输以及其膜结构的激发中发挥功能作用。这种超分子复合物似乎更容易被细胞效应器识别并发挥特定作用。
