Department of Cardiology, Lundquist Institute of Biomedical Research and Innovation, 1124 West Carson Street, Torrance, CA, 90502, USA.
Int J Cardiovasc Imaging. 2020 Dec;36(12):2335-2346. doi: 10.1007/s10554-020-01849-x. Epub 2020 Apr 19.
The purpose of this review is to highlight the utility of comprehensive plaque assessment by serial coronary computed tomography angiography (CCTA) to understand atherosclerosis and its effect on cardiovascular risk stratification and management. CCTA is a validated, noninvasive imaging modality for coronary atherosclerotic plaque characterization. Numerous clinical trials have used approach of serial CCTA to demonstrate the potential benefits of multiple treatment strategies to reduce coronary plaque progression and its translation to benefits with cardiovascular outcomes. Serial CCTA trials for cardiovascular therapies combined with clinical outcome studies are providing mechanistic correlations of coronary atherogenesis and cardiovascular risk reduction, thereby establishing a new standard of care in addressing cardiac disease. Advancements in CCTA imaging and plaque analysis continue to expand the potential for CCTA in the evaluation of cardiovascular risk and targeted treatment of CAD.
本综述旨在强调通过连续冠状动脉计算机断层扫描血管造影术（CCTA）进行全面斑块评估的效用，以了解动脉粥样硬化及其对心血管风险分层和管理的影响。CCTA 是一种经过验证的、非侵入性的冠状动脉粥样硬化斑块特征成像方式。许多临床试验都采用连续 CCTA 方法来证明多种治疗策略减少冠状动脉斑块进展及其转化为心血管结局获益的潜力。心血管治疗的连续 CCTA 试验与临床结果研究相结合，为冠状动脉粥样硬化形成和心血管风险降低的机制相关性提供了依据，从而在治疗心脏疾病方面确立了新的护理标准。CCTA 成像和斑块分析的进步不断扩大 CCTA 在评估心血管风险和靶向治疗 CAD 方面的潜力。
