Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Boston, MA, 02114, USA.
Department for Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.
Int J Cardiovasc Imaging. 2020 Dec;36(12):2305-2317. doi: 10.1007/s10554-020-01793-w. Epub 2020 Feb 19.
Change in coronary artery plaque on serial catheter intravascular ultrasound (IVUS) is an established technique to monitor the therapeutic effect of drugs on coronary atherosclerosis. Recent advances in coronary computed tomography angiography (CTA) now allow for non-invasive assessment of change in coronary plaque. Because coronary CTA is noninvasive, it enables clinical trials with lower-risk populations, higher retention rates, and lower costs. This review presents an overview of serial coronary CTA as a noninvasive imaging technique to gauge the therapeutic effect of anti-atherosclerotic therapies. Furthermore, it reviews the increasing use of serial CTA as an imaging endpoint in completed and ongoing clinical trials.
冠状动脉斑块的变化在连续导管血管内超声（IVUS）中是一种成熟的技术，用于监测药物对冠状动脉粥样硬化的治疗效果。最近，冠状动脉计算机断层扫描血管造影（CTA）的进展现在允许对冠状动脉斑块的变化进行非侵入性评估。由于冠状动脉 CTA 是一种非侵入性的方法，它可以使临床试验的风险人群更低、保留率更高、成本更低。本综述介绍了连续冠状动脉 CTA 作为一种非侵入性成像技术，用于评估抗动脉粥样硬化治疗的疗效。此外，还回顾了连续 CTA 作为已完成和正在进行的临床试验的成像终点的日益广泛应用。
