Department of Chemistry, The University of Georgia, Athens, Georgia, USA.
Magn Reson Chem. 2020 Dec;58(12):1187-1192. doi: 10.1002/mrc.5031. Epub 2020 Jun 21.
The instructional organic chemistry laboratory has been substantially improved through the implementation of benchtop NMR analysis. When used in conjunction with unknown reaction components in multi-outcome experiments, NMR analysis transforms the laboratory exercise into an investigative inquiry wherein students elucidate structures for their products and thereby deduce their unknown reaction components. This analytical approach closely models the research laboratory and is a valuable preparatory tool for undergraduate researchers. Three newly developed multi-outcome experiments based upon the Diels-Alder cycloaddition, the synthesis of carboxylic amides, and the Friedel-Crafts alkylation are herein described to illustrate the utility of benchtop NMR analysis in the instructional laboratory.
通过实施台式 NMR 分析，指导有机化学实验室得到了实质性的改进。当与多结果实验中的未知反应成分结合使用时，NMR 分析将实验室作业转变为调查探究，学生可以为其产物阐明结构，从而推断出未知的反应成分。这种分析方法与研究实验室非常相似，是本科生研究人员的宝贵预备工具。本文介绍了三个新开发的多结果实验，基于 Diels-Alder 环加成、羧酸酰胺的合成和 Friedel-Crafts 烷基化反应，以说明台式 NMR 分析在教学实验室中的应用。
