Departement of Immuno-Histo-Cytology, Salah Azaiez Cancer Institute, Tunis, Tunisia.
Research unit 17/ES/13 Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.
Cancer Invest. 2020 May;38(5):289-299. doi: 10.1080/07357907.2020.1758711. Epub 2020 May 1.
The aim was to evaluate the clinical impact of IGF-1/IGF-1R in Tunisian laryngeal carcinoma. A high IGF-1R immunohistochemical expression was found in our series (81.43%). A tendency toward an association between IGF-1R expression and lymph node metastasis was found ( = 0.068). Patients with positive IGF-1R expression showed a short disease free survival ( = 0.053) and a high recurrence rate. Furthermore, circulating IGF-1 levels sera, detected by ELISA, were higher among patients compared to controls ( < 0.001). IGF-1R might have a prognostic significance and could be a factor of tumor recurrence. However, high levels of IGF-1 increase the risk of developing of LSCC disease.
目的在于评估 IGF-1/IGF-1R 在突尼斯喉癌中的临床影响。在我们的研究中发现 IGF-1R 免疫组化表达较高（81.43%）。IGF-1R 表达与淋巴结转移之间存在相关性的趋势（=0.068）。IGF-1R 阳性表达的患者无疾病生存率较短（=0.053）且复发率较高。此外，通过 ELISA 检测到的血清循环 IGF-1 水平在患者中高于对照组（<0.001）。IGF-1R 可能具有预后意义，并且可能是肿瘤复发的因素。然而，IGF-1 水平升高会增加 LSCC 疾病发生的风险。
