Sturchio Elena, Berardinelli Maria Grazia, Boccia Priscilla, Zanellato Miriam, Gioiosa Silvia
Department of Technological Innovation and Safety of Plants, Product and Anthropic Settlements (DIT), Italian Workers' Compensation Authority (INAIL), Rome, Italy.
SCAI-Super Computing Applications and Innovation Department, CINECA, Rome, Italy.
Arch Environ Occup Health. 2020;75(8):471-482. doi: 10.1080/19338244.2020.1747966. Epub 2020 Apr 20.
Malignant mesothelioma is an aggressive tumor resistant to current therapies with a latency period ranging between 20 and 60 years, caused by inhalation of asbestos fibers, that continues to represent a social and healthcare issue. The high percentage of people exposed to asbestos for professional or environmental reasons is associated with the high biopersistence of its fibers and with its widespread use in the last century. Approximately 20-40% of men report an occupational history that might have caused the workplace exposure (criteria Helsinki, 1997). Some authors are evaluating the possible use of bioindicators as a screening and early diagnosis tool. In this regard, the use of microRNAs has been proposed as powerful diagnostic and prognostic biomarkers for many tumors and human diseases. This review focuses on the current state of knowledge on the key role of microRNAs expression as new malignant mesothelioma biomarkers, in early clinical diagnostic applications.
恶性间皮瘤是一种侵袭性肿瘤，对当前治疗具有抗性，潜伏期为20至60年，由吸入石棉纤维引起，它仍然是一个社会和医疗问题。由于职业或环境原因接触石棉的人群比例很高，这与其纤维的高生物持久性及其在上个世纪的广泛使用有关。大约20-40%的男性报告有可能导致工作场所接触石棉的职业史（赫尔辛基标准，1997年）。一些作者正在评估生物标志物作为筛查和早期诊断工具的可能用途。在这方面，有人提出将微小RNA用作许多肿瘤和人类疾病的强大诊断和预后生物标志物。本综述重点关注微小RNA表达作为新的恶性间皮瘤生物标志物在早期临床诊断应用中的关键作用的当前知识状态。
