Wayne State University School of Medicine, Detroit, MI, USA.
Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Cardiol Young. 2020 May;30(5):686-691. doi: 10.1017/S1047951120000785. Epub 2020 Apr 20.
To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD.
A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery.
Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06-2.10).
Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.
评估胎儿先天性心脏病（CHD）产前诊断的分娩管理和结局。
对 6194 例胎儿（2013 年至 2016 年出生）进行回顾性队列研究，将产前诊断为 CHD（170 例）与非心脏畸形（234 例）和无畸形（5790 例）胎儿进行比较。主要结局包括早产发生率和分娩方式。
CHD 组和无畸形组的分娩孕周明显较低（分别为 38.6 周和 39.1 周）。患有 CHD 的新生儿出生体重明显较低（p < 0.001）。与产前诊断为 CHD 相关的初次剖宫产率约增加了 1.5 倍，优势比为 1.49（95%CI 1.06-2.10）。
本研究进一步证明，产前诊断 CHD 与出生体重低、早产和初次剖宫产风险增加有关。
