Valrie Cecelia, Floyd Alfonso, Sisler India, Redding-Lallinger Rupa, Fuh Beng
Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Institute for Inclusion, Inquiry, and Innovation, Virginia Commonwealth University, Richmond, VA, USA.
J Pain Res. 2020 Apr 8;13:729-736. doi: 10.2147/JPR.S238115. eCollection 2020.
Youth with sickle cell disease (SCD), a genetic disorder of red blood cells, may experience acute pain episodes lasting 2 to 3 days on average. While existing research has demonstrated associations between SCD pain and poor social functioning in youth with SCD, there are no data on whether symptoms of depression and anxiety modify the relationship between pain and functional outcomes in pediatric pain populations. It was hypothesized that more symptoms of depression and anxiety would exacerbate the relationship between high pain and poor social functioning in youth with SCD.
We conducted a cross-sectional study of 114 youth with SCD and their guardians assessing the youth's pain, social functioning, and symptoms of depression and anxiety.
Analyses indicated that elevated levels of depressive symptoms were related to poorer self-reported interpersonal skills. More anxiety symptoms were related to better guardian-reported social skills and weakened the relationship between high pain frequency and poor self-reported interpersonal skills.
Findings build on previous work supporting the need for multidisciplinary approaches to care for youth with SCD who experience pain, and provide rationale for future studies to investigate the direct and possible moderating effects of depression and anxiety symptoms on other functional outcomes in youth with SCD and other pediatric pain populations.
患有镰状细胞病（SCD）的青少年，这是一种红细胞的遗传性疾病，可能平均经历持续2至3天的急性疼痛发作。虽然现有研究表明SCD疼痛与患有SCD的青少年社会功能不良之间存在关联，但尚无关于抑郁和焦虑症状是否会改变儿科疼痛人群中疼痛与功能结局之间关系的数据。据推测，更多的抑郁和焦虑症状会加剧患有SCD的青少年中高疼痛与社会功能不良之间的关系。
我们对114名患有SCD的青少年及其监护人进行了一项横断面研究，评估了青少年的疼痛、社会功能以及抑郁和焦虑症状。
分析表明，抑郁症状水平升高与自我报告的人际交往能力较差有关。更多的焦虑症状与监护人报告的更好的社交技能有关，并削弱了高疼痛频率与自我报告的人际交往能力较差之间的关系。
研究结果建立在先前工作的基础上，支持对经历疼痛的患有SCD的青少年需要采取多学科护理方法，并为未来研究调查抑郁和焦虑症状对患有SCD的青少年和其他儿科疼痛人群的其他功能结局的直接和可能的调节作用提供了理论依据。
