Centre for Tumor Microenvironment, Barts Cancer Institute, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
Institute of Vascular Biology, Medical University of Vienna, 1090 Vienna, Austria.
Theranostics. 2020 Apr 6;10(11):5074-5089. doi: 10.7150/thno.42441. eCollection 2020.
In tumor engineering, 3D approaches are used to model components of the tumor microenvironment and to test new treatments. Pancreatic cancers are a cancer of substantial unmet need and survival rates are lower compared to any other cancer. Bioengineering techniques are increasingly applied to understand the unique biology of pancreatic tumors and to design patient-specific models. Here we summarize how extracellular and cellular elements of the pancreatic tumor microenvironment and their interactions have been studied in 3D cell cultures. We review selected clinical trials, assess the benefits of therapies interfering with the tumor microenvironment and address their limitations and future perspectives.
在肿瘤工程中，3D 方法被用于模拟肿瘤微环境的成分，并测试新的治疗方法。胰腺癌是一种未满足需求的癌症，其存活率低于其他任何癌症。生物工程技术越来越多地被应用于了解胰腺肿瘤的独特生物学特性，并设计针对患者的模型。在这里，我们总结了 3D 细胞培养中如何研究胰腺肿瘤微环境的细胞外和细胞成分及其相互作用。我们回顾了一些临床试验，评估了干预肿瘤微环境的疗法的益处，并探讨了它们的局限性和未来前景。
