Department of Molecular & Cellular Biology, School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, 5005, Australia.
Discipline of Medicine, School of Medicine, The University of Adelaide, Adelaide, South Australia, 5000, Australia.
Curr Diab Rep. 2019 Jul 4;19(8):53. doi: 10.1007/s11892-019-1166-x.
Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell biology has provided the means to overcome these challenges.
3D bioprinting allows for the precise fabrication of complex 3D architectures containing spatially distributed cells, biomaterials (bioink), and bioactive factors. Different strategies to capitalize on this ability have been investigated for the 3D bioprinting of pancreatic islets. In particular, with co-axial bioprinting technology, the co-printability of islets with supporting cells such as endothelial progenitor cells and regulatory T cells, which have been shown to accelerate revascularization of islets and improve the outcome of various transplantations, respectively, has been achieved. 3D bioprinting of islets for generation of an artificial pancreas is a newly emerging field of study with a vast potential to improve islet transplantation.
胰岛细胞移植是目前治疗 1 型糖尿病的唯一有治愈可能的细胞疗法。然而，由于面临一些挑战，其应用于更多患者的潜力受到了限制。近年来，3D 打印技术、生物材料和细胞生物学的进步催生了 3D 生物打印技术，为克服这些挑战提供了手段。
3D 生物打印允许精确制造包含空间分布细胞、生物材料（生物墨水）和生物活性因子的复杂 3D 结构。为了利用这一能力，人们研究了多种策略来进行胰岛的 3D 生物打印。特别是，通过共轴生物打印技术，已经实现了将胰岛与支持细胞（如内皮祖细胞和调节性 T 细胞）共打印的可行性，这些支持细胞分别被证明可以加速胰岛的再血管化并改善各种移植的效果。用于生成人工胰腺的胰岛 3D 生物打印是一个新兴的研究领域，具有极大的潜力来改善胰岛移植。
