Moradian Siamak, Ebrahimi Marzieh, Kanaani Azade, Faramarzi Amir, Safi Sare
Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2020 Apr 6;15(2):160-165. doi: 10.18502/jovr.v15i2.6732. eCollection 2020 Apr-Jun.
To evaluate the role of topical umbilical cord serum (TUCS) therapy in treating corneal epithelial defects (CEDs) after diabetic vitrectomy.
In this double-masked, randomized clinical trial, we included 80 eyes of 80 patients who were candidates for vitrectomy due to proliferative diabetic retinopathy complications. In cases of corneal edema obscuring the fundus view during surgery, the corneal epithelium was removed using a 6-mm trephine and a blade no.15. The day after the surgery, patients were randomly divided into two groups: (1) the TUCS group that received 20% TUCS six times/day in addition to the conventional treatment of CED and (2) the control group, which was prescribed artificial tears as placebo in addition to the conventional treatment of CED. The rate of healing of CEDs was measured via two maximum linear dimensions perpendicular to each other at the start of therapy and on postoperative days 1-5, 7, and 12.
Of 80 eyes, 40 were assigned to each treatment group. The mean times to complete CED healing were 2.4 0.7 and 3.8 2.1 days in the TUCS and control groups, respectively ( 0.001). Persistent CED occurred in two eyes in the control group but in no eyes in the TUCS group.
TUCS therapy may be safe and effective in healing CEDs after vitrectomy in patients with diabetes.
评估局部应用脐带血清（TUCS）疗法在治疗糖尿病玻璃体切除术后角膜上皮缺损（CED）中的作用。
在这项双盲随机临床试验中，我们纳入了80例因增殖性糖尿病视网膜病变并发症而需行玻璃体切除术的患者的80只眼。对于手术中因角膜水肿而遮挡眼底视野的病例，使用6毫米环钻和15号刀片去除角膜上皮。术后第一天，患者被随机分为两组：（1）TUCS组，除常规治疗CED外，每天6次接受20% TUCS治疗；（2）对照组，除常规治疗CED外，给予人工泪液作为安慰剂。在治疗开始时以及术后第1 - 5天、第7天和第12天，通过相互垂直的两个最大线性维度测量CED的愈合率。
80只眼中，每组各分配40只眼。TUCS组和对照组完成CED愈合的平均时间分别为2.4±0.7天和3.8±2.1天（P<0.001）。对照组有2只眼出现持续性CED，而TUCS组无此情况。
TUCS疗法对于糖尿病患者玻璃体切除术后CED的愈合可能是安全有效的。
