Gleason Joseph D, Oishi Meeko, Simkulet Michelle, Tuzikas Arunas, Hanifin John P, Brainard George C, Brueck S R J, Karlicek Robert F, Brown Lee K
1Electrical and Computer EngineeringUniversity of New MexicoAlbuquerqueNM87131USA.
2Lighting Enabled Systems and Applications Engineering Research CenterRensselaer Polytechnic InstituteTroyNY12189USA.
IEEE J Transl Eng Health Med. 2019 Aug 30;7:3200110. doi: 10.1109/JTEHM.2019.2937957. eCollection 2019.
Lighting is a strong synchronizer for circadian rhythms, which in turn drives a wide range of biological functions. The objective of our work is a) to construct a clinical in-patient testbed with smartİ lighting, and b) evaluate its feasibility for use in future clinical studies.
A feedback capable, variable spectrum lighting system was installed at the University of New Mexico Hospital. The system consists of variable spectrum lighting troffers, color sensors, occupancy sensors, and computing and communication infrastructure. We conducted a pilot study to demonstrate proof of principle, that 1) this new technology is capable of providing continuous lighting and sensing in an active clinical environment, 2) subject recruitment and retention is feasible for round-the-clock, multi-day studies, and 3) current techniques for circadian regulation can be deployed in this unique testbed. Unlike light box studies, only troffer-based lighting was used, and both lighting intensity and spectral content were varied.
The hardware and software functioned seamlessly to gather biometric data and provide the desired lighting. Salivary samples that measure dim-light melatonin onset showed phase advancement for all three subjects.
We executed a five-day circadian rhythm study that varied intensity, spectrum, and timing of lighting as proof-of-concept or future clinical studies with troffer-based, variable spectrum lighting. Clinical Impact: The ability to perform circadian rhythm experiments in more realistic environments that do not overly constrain the subject is important for translating lighting research into practice, as well as for further research on the health impacts of lighting.
光照是昼夜节律的强大同步器，而昼夜节律又驱动着广泛的生物学功能。我们工作的目标是：a）构建一个配备智能照明的临床住院患者试验台，b）评估其在未来临床研究中使用的可行性。
在新墨西哥大学医院安装了一个具有反馈功能的可变光谱照明系统。该系统由可变光谱照明灯具、颜色传感器、占用传感器以及计算和通信基础设施组成。我们进行了一项试点研究以证明原理，即1）这项新技术能够在活跃的临床环境中提供持续照明和传感，2）对于全天候、多天的研究，招募和留住受试者是可行的，3）当前的昼夜节律调节技术可部署在这个独特的试验台中。与灯箱研究不同，仅使用基于灯具的照明，并且照明强度和光谱内容均会变化。
硬件和软件无缝运行以收集生物特征数据并提供所需照明。测量暗光褪黑素起始时间的唾液样本显示，所有三名受试者的相位均提前。
我们进行了一项为期五天的昼夜节律研究，该研究改变了照明的强度、光谱和时间，以此作为基于灯具的可变光谱照明的概念验证或未来临床研究。临床影响：在不过度限制受试者的更现实环境中进行昼夜节律实验的能力，对于将照明研究转化为实际应用以及进一步研究照明对健康的影响都很重要。
