Alhatem Albert, Patel Krishan, Eriksen Brenda, Bukhari Sarosh, Liu Chen
Department of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ.
Rutgers New Jersey Medical School, Newark, NJ.
ACG Case Rep J. 2019 Nov 28;6(11):e00249. doi: 10.14309/crj.0000000000000249. eCollection 2019 Nov.
Immunotherapy agents such as cytotoxic T-lymphocyte antigen-4 and programed cell death protein-1 inhibitors show efficacy in cancer therapy but are associated with immune-related adverse events. It commonly presents as diarrhea but can cause colitis, mimicking inflammatory bowel disease. Our patient is a 78-year-old man on nivolumab therapy for metastatic lung cancer who developed new onset nausea and diarrhea. Endoscopy revealed inflammation of the upper and lower gastrointestinal tract, and histology revealed transmural colon and gastric inflammation. We present a fascinating case of severe concomitant aphthous ulcers, esophagitis, gastritis, and enterocolitis.
免疫治疗药物，如细胞毒性T淋巴细胞抗原4和程序性细胞死亡蛋白1抑制剂，在癌症治疗中显示出疗效，但与免疫相关的不良事件有关。它通常表现为腹泻，但也可引起结肠炎，类似于炎症性肠病。我们的患者是一名78岁男性，正在接受纳武单抗治疗转移性肺癌，出现了新发的恶心和腹泻。内镜检查显示上、下消化道炎症，组织学检查显示全层结肠和胃炎症。我们报告了一例伴有严重口疮性溃疡、食管炎、胃炎和小肠结肠炎的罕见病例。
