Boike Justin, Dejulio Todd
Division of Gastroenterology and Hepatology, Northwestern University, Chicago, IL.
Division of Anatomic and Clinical Pathology, Northwestern University, Chicago, IL.
ACG Case Rep J. 2017 Apr 12;4:e57. doi: 10.14309/crj.2017.57. eCollection 2017.
Nivolumab is a novel chemotherapy currently approved for the treatment of multiple metastatic malignancies. This class of therapy, known as immune checkpoint inhibitors, is notable for an autoimmune-related adverse event profile. Diarrhea and colitis are common gastrointestinal adverse events, however, upper gastrointestinal events are rarely reported. We present a case of nivolumab-associated esophagitis and gastritis that has yet to be reported in the published literature.
纳武单抗是一种目前已被批准用于治疗多种转移性恶性肿瘤的新型化疗药物。这类疗法被称为免疫检查点抑制剂，以其与自身免疫相关的不良事件谱而闻名。腹泻和结肠炎是常见的胃肠道不良事件，然而，上消化道事件鲜有报道。我们报告一例纳武单抗相关的食管炎和胃炎病例，该病例在已发表的文献中尚未见报道。
