Wiweko Budi, Handayani Lieke Koes, Harzif Achmad Kemal, Pratama Gita, Muharam Raden, Hestiantoro Andon, Sumapraja Kanadi
Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia.
Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia.
Int J Reprod Biomed. 2020 Mar 29;18(3):187-192. doi: 10.18502/ijrm.v18i3.6716. eCollection 2020 Mar.
Various endocrine disorders have been reported in women of reproductive age, 10% of which is affected by polycystic ovary syndrome (PCOS).
This study aimed to evaluate the correlation of anti-Müllerian hormone (AMH) levels with the metabolic syndrome in patients with PCOS.
This cross-sectional study employed a consecutive sampling method using medical records from January 2013 to December 2017 at Dr. Cipto Mangunkusumo General Hospital polyclinic and Yasmin in vitro fertilization Clinic (Kencana), Jakarta, Indonesia. The primary outcome of the study was the AMH levels as independent variable correlated with metabolic syndrome. The secondary outcome was also the AMH levels correlated with each PCOS phenotype. The tertiary outcome was each PCOS phenotype as independent variable correlated with metabolic syndrome.
Women with phenotype 1 of PCOS had a median AMH level of 13.92 (range: 3.88-34.06) ng/ml. 21% patients had metabolic syndrome, with a median AMH level 7.65 (3.77-20.20) ng/ml, higher than the women without metabolic syndrome (p = 0.38). The most frequent phenotype in women with PCOS was phenotype 4, oligo- or anovulation and polycystic ovary morphology (OA/PCOM) in 41.3%. The most frequent phenotype in women with metabolic syndrome was phenotype 1, OA + PCOM + hyperandrogenism in 56.5%.
All PCOS phenotypes exhibited significant correlations with the AMH level. Phenotype 1 (OA + PCOM + hyperandrogenism) was associated with the highest AMH level and was significantly associated with metabolic syndrome.
已有报道称育龄期女性存在各种内分泌紊乱，其中10%受多囊卵巢综合征（PCOS）影响。
本研究旨在评估多囊卵巢综合征患者抗苗勒管激素（AMH）水平与代谢综合征之间的相关性。
本横断面研究采用连续抽样方法，使用印度尼西亚雅加达Cipto Mangunkusumo综合医院门诊部和Yasmin体外受精诊所（Kencana）2013年1月至2017年12月的病历。该研究的主要结局是作为自变量的AMH水平与代谢综合征的相关性。次要结局也是AMH水平与每种PCOS表型的相关性。第三结局是每种PCOS表型作为自变量与代谢综合征的相关性。
PCOS表型1的女性AMH水平中位数为13.92（范围：3.88 - 34.06）ng/ml。21%的患者患有代谢综合征，其AMH水平中位数为7.65（3.77 - 20.20）ng/ml，高于无代谢综合征的女性（p = 0.38）。PCOS女性中最常见的表型是表型4，即少排卵或无排卵以及多囊卵巢形态（OA/PCOM），占41.3%。患有代谢综合征的女性中最常见的表型是表型1，即OA + PCOM + 高雄激素血症，占56.5%。
所有PCOS表型均与AMH水平存在显著相关性。表型1（OA + PCOM + 高雄激素血症）与最高的AMH水平相关，且与代谢综合征显著相关。
