Department of Chemistry, Fukushima Medical University, Fukushima 960-1295, Japan.
J Org Chem. 2020 May 15;85(10):6528-6534. doi: 10.1021/acs.joc.0c00487. Epub 2020 Apr 29.
The zinc-catalyzed regioselective hydrothiolation of alkenes with thiols was achieved in the presence of 4-toluenesulfonic acid. Through this procedure, Markovnikov-type sulfides were synthesized in excellent yields, and the formation of anti-Markovnikov-type sulfides was suppressed. Furthermore, the combination of numerous aryl alkenes with arenethiols or alkyl thiols was achieved using the procedure.
在对甲苯磺酸存在下，实现了烯烃与硫醇的锌催化区域选择性氢硫加成反应。通过该方法，以优异的收率合成了马氏规则型硫醚，同时抑制了反马氏规则型硫醚的生成。此外，该方法还可实现多种芳基烯烃与芳基硫醇或烷基硫醇的组合。
