CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Institut de Génomique Fonctionnelle de Lyon (IGFL), École Normale Supérieure de Lyon, Lyon, France.
Biochem Soc Trans. 2020 Apr 29;48(2):463-478. doi: 10.1042/BST20190390.
During the development of multicellular organisms, transcriptional regulation plays an important role in the control of cell growth, differentiation and morphogenesis. SUMOylation is a reversible post-translational process involved in transcriptional regulation through the modification of transcription factors and through chromatin remodelling (either modifying chromatin remodelers or acting as a 'molecular glue' by promoting recruitment of chromatin regulators). SUMO modification results in changes in the activity, stability, interactions or localization of its substrates, which affects cellular processes such as cell cycle progression, DNA maintenance and repair or nucleocytoplasmic transport. This review focuses on the role of SUMO machinery and the modification of target proteins during embryonic development and organogenesis of animals, from invertebrates to mammals.
在多细胞生物的发育过程中，转录调控在控制细胞生长、分化和形态发生方面起着重要作用。SUMOylation 是一种涉及转录因子修饰和染色质重塑的可逆翻译后过程（通过修饰染色质重塑因子或作为“分子胶”通过促进染色质调节因子的募集来发挥作用）。SUMO 修饰导致其底物的活性、稳定性、相互作用或定位发生变化，从而影响细胞过程，如细胞周期进程、DNA 维持和修复或核质运输。这篇综述重点介绍了 SUMO 机器及其在从无脊椎动物到哺乳动物的动物胚胎发育和器官发生过程中对靶蛋白的修饰作用。
