未折叠蛋白反应（UPR）控制主要的衰老特征。
Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks.
作者信息
Abbadie Corinne, Pluquet Olivier
机构信息
University of Lille, CNRS, Inserm, CHU Lille, Institute Pasteur de Lille, UMR 9020-UMR-S1277 - Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, France.
University of Lille, CNRS, Inserm, CHU Lille, Institute Pasteur de Lille, UMR 9020-UMR-S1277 - Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, France.
出版信息
Trends Biochem Sci. 2020 May;45(5):371-374. doi: 10.1016/j.tibs.2020.02.005. Epub 2020 Mar 4.
Senescence is a complex cellular state, which can be considered as a stress response phenotype. However, the mechanisms through which cells acquire and maintain this phenotype are not fully understood. In this paper, it is argued that the unfolded protein response (UPR) may represent a signalling platform that is associated with the major senescence hallmarks.
衰老 是一种复杂的细胞状态，可被视为一种应激反应表型。然而，细胞获得并维持这种表型的机制尚未完全明确。本文认为，未折叠蛋白反应（UPR）可能代表了一个与主要衰老特征相关的信号平台。
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