Matos Diana, Sá Carina, Cardoso Paulo, Pires Adília, Figueira Etelvina
Department of Biology, University of Aveiro, Aveiro, Portugal.
Department of Biology & CESAM, University of Aveiro, Aveiro, Portugal.
J Hazard Mater. 2020 Aug 5;395:122629. doi: 10.1016/j.jhazmat.2020.122629. Epub 2020 Apr 7.
α,β-unsaturated aldehydes are generally reported as being toxic, however for saturated aldehydes information is scarce. Here we report the effects on growth and biochemical endpoints related to oxidative stress of Rhizobium colonies under airborne exposure to C6 to C13 saturated aliphatic aldehydes and exposed or not to Cd. Smaller aldehydes (C6 to C10) and larger aldehydes (C11 to C13) had distinct effects on cell biochemistry. Smaller aldehydes reduced and larger ones increased lipid peroxidation. The activity of superoxide dismutase was also decreased by smaller aldehydes and increased by the larger ones. Thus, even an exposure at a distance to saturated aldehydes is able to influence the biochemical status of bacterial cells, and the effects appear to be dependent on the size and thus on distinct properties (e.g. volatility and liposolubility). Moreover, some aldehydes (the smaller saturated ones) may even have a beneficial effect, that switches when cells are in oxidative stress (exposed to Cd). This influence can be used in different contexts, by increasing the resilience of bacterial communities to environmental contaminants with oxidizing effect or by sensitizing bacteria to antimicrobial agents.
一般报道称α,β-不饱和醛具有毒性，然而关于饱和醛的信息却很匮乏。在此，我们报告了在空气中暴露于C6至C13饱和脂肪醛且暴露或未暴露于镉的情况下，根瘤菌菌落的生长及与氧化应激相关的生化指标所受的影响。较小的醛（C6至C10）和较大的醛（C11至C13）对细胞生物化学有不同影响。较小的醛降低了脂质过氧化，而较大的醛则增加了脂质过氧化。超氧化物歧化酶的活性也因较小的醛而降低，因较大的醛而增加。因此，即使在一定距离外暴露于饱和醛也能够影响细菌细胞的生化状态，而且这种影响似乎取决于醛的大小，进而取决于不同的特性（如挥发性和脂溶性）。此外，一些醛（较小的饱和醛）甚至可能具有有益作用，当细胞处于氧化应激状态（暴露于镉）时这种作用会发生转变。这种影响可用于不同情境，通过增强细菌群落对具有氧化作用的环境污染物的恢复力，或使细菌对抗菌剂更敏感。
