具有氧化酶模拟活性的钴基氧氢氧化物纳米薄片诱导鲁米诺化学发光用于谷胱甘肽检测。
Cobalt oxyhydroxide nanoflakes with oxidase-mimicking activity induced chemiluminescence of luminol for glutathione detection.
机构信息
Key Laboratory of Luminescent and Real-Time Analytical System (Southwest University), Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.
Key Laboratory of Luminescent and Real-Time Analytical System (Southwest University), Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.
出版信息
Talanta. 2020 Aug 1;215:120928. doi: 10.1016/j.talanta.2020.120928. Epub 2020 Mar 17.
Cobalt oxyhydroxide nanoflakes (CoOOH NFs), a typical two-dimensional (2D) nanomaterials, were found to induce chemiluminescence (CL) of luminol since the oxidase-like activity of CoOOH NFs enables the dissolved oxygen to generate various radicals (OH, Oand O) even if without the addition of oxidants such as hydrogen peroxide, and these radicals could be scavenged by glutathione (GSH), making GSH could be detected sensitively in the range of 10 nM to 1 μM with the detection limit of 6.4 nM.
钴氧氢氧化物纳米片（CoOOH NF），一种典型的二维（2D）纳米材料，被发现能够诱导鲁米诺的化学发光（CL），因为 CoOOH NF 的类氧化酶活性使得溶解氧即使在没有添加过氧化物等氧化剂的情况下也能产生各种自由基（OH、O 和 O），而这些自由基可以被谷胱甘肽（GSH）清除，从而使 GSH 能够在 10 nM 至 1 μM 的范围内被灵敏地检测到，检测限为 6.4 nM。
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