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Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19.

作者信息

Hoffmann Markus, Schroeder Simon, Kleine-Weber Hannah, Müller Marcel A, Drosten Christian, Pöhlmann Stefan

机构信息

Deutsches Primatenzentrum-Leibniz Institute for Primate Research, Göttingen, Germany.

Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany.

出版信息

Antimicrob Agents Chemother. 2020 May 21;64(6). doi: 10.1128/AAC.00754-20.

DOI:10.1128/AAC.00754-20
PMID:32312781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7269515/
Abstract
摘要

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型(SARS-CoV-2)进入细胞依赖于 ACE2 和 TMPRSS2,可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
2
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.瑞德西韦和氯喹在体外能有效抑制新出现的新型冠状病毒(2019 - 新冠病毒)。
Cell Res. 2020 Mar;30(3):269-271. doi: 10.1038/s41422-020-0282-0. Epub 2020 Feb 4.
3
TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection.
弹性蛋白酶和跨膜丝氨酸蛋白酶2对蝙蝠SARS样冠状病毒刺突蛋白的协同激活作用
Sci Rep. 2025 Jul 21;15(1):26469. doi: 10.1038/s41598-025-11600-y.
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Overview of host-directed antiviral targets for future research and drug development.未来研究和药物开发的宿主导向抗病毒靶点概述。
Acta Pharm Sin B. 2025 Apr;15(4):1723-1751. doi: 10.1016/j.apsb.2025.03.011. Epub 2025 Mar 8.
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Drug discovery and development targeting the life cycle of SARS-CoV-2.针对新型冠状病毒生命周期的药物发现与开发。
Fundam Res. 2021 Mar;1(2):151-165. doi: 10.1016/j.fmre.2021.01.013. Epub 2021 Feb 1.
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TMPRSS2 促进冠状病毒感染后小鼠模型呼吸道中的病毒传播和免疫病理。
J Virol. 2019 Mar 5;93(6). doi: 10.1128/JVI.01815-18. Print 2019 Mar 15.
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Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.证据表明 TMPRSS2 激活严重急性呼吸综合征冠状病毒刺突蛋白进行膜融合,并降低体液免疫应答对病毒的控制。
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A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.一种跨膜丝氨酸蛋白酶与严重急性呼吸综合征冠状病毒受体相连,并激活病毒进入。
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Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.高效激活严重急性呼吸综合征冠状病毒刺突蛋白需要跨膜蛋白酶 TMPRSS2。
J Virol. 2010 Dec;84(24):12658-64. doi: 10.1128/JVI.01542-10. Epub 2010 Oct 6.