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[一例酷似脑挫裂伤的原发性颅内恶性黑色素瘤病例]

[A Case of Primary Intracranial Malignant Melanoma Mimicking a Traumatic Brain Contusion].

作者信息

Tanabe Noriaki, Toyooka Terushige, Endo Arumu, Doi Kazuma, Miyama Masataka, Takeuchi Satoru, Tomiyama Arata, Otani Naoki, Tomura Satoshi, Wada Kojiro, Mori Kentaro

机构信息

Department of Neurosurgery, National Defense Medical College Hospital.

出版信息

No Shinkei Geka. 2020 Apr;48(4):341-347. doi: 10.11477/mf.1436204188.

Abstract

Primary intracranial malignant melanoma(PIMM)is a rare neoplasm of the central nervous system, accounting for 1% of cases of malignant melanomas and 0.1% of cases of brain tumors. Here, we report a case of PIMM that was initially considered to be a traumatic brain contusion. A 44-year-old man was transferred to a local hospital because of general tonic convulsion after falling while riding a bike. CT showed an irregular high-density area in the left temporal pole, which was diagnosed as a traumatic contusion. MRI performed 3 months after the initial episode revealed an enlarged temporal lesion with surrounding edema, suggestive of a neoplasm. The MRI showed the lesion as mixed signal intensity, suggesting both solid and cystic components. Subtotal resection was performed, except for the tumor adhering to the peripheral middle cerebral arteries(MCAs). The definitive diagnosis was made based on pathological findings and no evidence of extracranial lesions. Gamma knife surgery was performed for the remnant tumor adjacent to MCAs. The radiologically positive tumor chronologically regressed, and the patient remained progression-free for 18 months. Radiological findings of PIMM vary but typically include high density on CT and hyperintensity on T1-weighted MRI. Close observation enabled early diagnosis based on the suspicion of a neoplasm according to atypical radiological findings. PIMM has a poor prognosis with an overall survival of 12.0 months without confirmative treatment. Gamma knife surgery might achieve suppression of this highly progressive tumor.

摘要

原发性颅内恶性黑色素瘤(PIMM)是一种罕见的中枢神经系统肿瘤,占恶性黑色素瘤病例的1%,脑肿瘤病例的0.1%。在此,我们报告一例最初被认为是脑挫裂伤的PIMM病例。一名44岁男性因骑自行车摔倒后全身强直抽搐被转至当地医院。CT显示左侧颞极有不规则高密度区,被诊断为外伤性挫伤。初次发病3个月后进行的MRI显示颞叶病变增大并伴有周围水肿,提示为肿瘤。MRI显示病变为混合信号强度,提示既有实性成分又有囊性成分。除与大脑中动脉(MCA)外周粘连的肿瘤外,进行了次全切除。根据病理结果及无颅外病变证据做出明确诊断。对与MCA相邻的残余肿瘤进行了伽玛刀手术。影像学上呈阳性的肿瘤按时间顺序逐渐消退,患者18个月无进展。PIMM的影像学表现各异,但通常包括CT上的高密度和T1加权MRI上的高信号。密切观察可根据非典型影像学表现怀疑肿瘤从而实现早期诊断。未经确诊治疗的PIMM预后较差,总生存期为12.0个月。伽玛刀手术可能会抑制这种高度进展性肿瘤。

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