Hirota Kengo, Yoshimura Chika, Kubo Osami, Kasuya Hidetoshi
Department of Neurosurgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
J Korean Neurosurg Soc. 2017 Jan 1;60(1):98-101. doi: 10.3340/jkns.2015.0506.007. Epub 2016 Dec 29.
We report a case of primary intracranial malignant melanoma (PIMM) with extracranial metastases. The patient was an 82-year-old woman diagnosed with PIMM under the left cerebellar tentorium. We performed a tumor resection followed by gamma knife surgery. An magnetic resonance imaging at 11 months after surgery showed a local intracranial recurrence. At 12 months, vertebral metastasis was suspected, and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) showed multiple extracranial metastases. She died at 13 months after surgery. Although extracranial metastases of PIMM are extremely rare, we should carefully follow up extracranial metastases together with intracranial ones, especially by FDG-PET/CT, even at an early asymptomatic stage.
我们报告一例原发性颅内恶性黑色素瘤(PIMM)伴颅外转移的病例。患者为一名82岁女性,诊断为左侧小脑幕下的PIMM。我们进行了肿瘤切除术,随后进行了伽玛刀手术。术后11个月的磁共振成像显示颅内局部复发。在12个月时,怀疑有椎体转移,2-[氟-18]-氟-2-脱氧-D-葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)显示多处颅外转移。她在术后13个月死亡。尽管PIMM的颅外转移极为罕见,但我们应仔细随访颅外转移以及颅内转移情况,尤其是通过FDG-PET/CT进行随访,即使在早期无症状阶段也应如此。