Marine Ecosystem and Biological Research Center, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea.
Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, Republic of Korea.
Sci Rep. 2020 Apr 20;10(1):6620. doi: 10.1038/s41598-020-62867-2.
Balneotherapy is a common non-pharmacological treatment for osteoarthritis (OA), however, the efficacy is controversial in knee OA. Jeju magma-seawater (JMS) has high contents of various minerals, which has anti-inflammatory and antioxidant properties via an oral route. Thus, we examined the effects of JMS bathing on knee OA and the combination effects with diclofenac sodium as an anti-inflammatory drug. Knee OA was induced by transection of the anterior cruciate ligament and the partial meniscectomy in rat. The rats were administered subcutaneously saline or diclofenac sodium in saline, followed by bathing in thermal distilled water or JMS for 8 weeks. The model represented the characteristic changes of the cartilage degradation, osteophyte formation and synovial inflammation, and the relevant symptoms of the joint swelling and stiffness. However, the JMS bathing reduced the joint thickness and improved the mobility. It also contributed to a well-preserved tissue supported by increases in bone mineral density of the joint and decreases in Mankin scores in the cartilages. The effects involved anti-inflammation, chondroprotection, anti-apoptosis, and chondrogenesis. Overall, the JMS bathing in combination with diclofenac sodium showed a similar trend associated with synergic effects. It suggests that JMS bathing can be promising for a clinical use in knee OA.
水疗法是一种常见的非药物治疗骨关节炎（OA）的方法，但对于膝骨关节炎（KOA）的疗效存在争议。济州岩浆海水（JMS）含有丰富的各种矿物质，通过口服具有抗炎和抗氧化作用。因此，我们研究了 JMS 沐浴对膝骨关节炎的影响，以及与双氯芬酸钠（一种抗炎药）联合应用的效果。在大鼠中通过前交叉韧带切断和部分半月板切除术诱导膝骨关节炎。大鼠皮下给予生理盐水或生理盐水中的双氯芬酸钠，然后在热蒸馏水中或 JMS 中沐浴 8 周。该模型代表了软骨降解、骨赘形成和滑膜炎的特征性变化，以及关节肿胀和僵硬的相关症状。然而，JMS 沐浴减轻了关节厚度并改善了运动能力。它还通过增加关节骨密度和降低软骨中的 Mankin 评分来促进组织的保存。这些作用涉及抗炎、软骨保护、抗细胞凋亡和软骨形成。总的来说，JMS 沐浴与双氯芬酸钠联合使用表现出相似的趋势，具有协同作用。这表明 JMS 沐浴在膝骨关节炎的临床应用中具有广阔的前景。
