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一名50岁男性的早期IgD型多发性骨髓瘤。

Early stage IgD multiple myeloma in a 50-year-old man.

作者信息

Lake Littlejohn C, Whiteley Andrew, Stone Marvin J

机构信息

Department of Internal Medicine, Baylor University Medical CenterDallasTexas.

Department of Oncology, Charles A. Sammons Cancer Center, Baylor University Medical CenterDallasTexas.

出版信息

Proc (Bayl Univ Med Cent). 2019 Dec 23;33(2):263-265. doi: 10.1080/08998280.2019.1698878. eCollection 2020 Apr.

DOI:10.1080/08998280.2019.1698878
PMID:32313482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7155962/
Abstract

We present the case of a 50-year-old Hispanic man who presented to the emergency department with an acute right femur fracture after 3 months of intermittent discomfort in the right leg. He was eventually diagnosed with immunoglobulin D (IgD) multiple myeloma, a rare class of myeloma that is often of advanced stage at diagnosis. Fortunately, our patient was stage I at diagnosis and did not have hypercalcemia, anemia, or renal insufficiency, as is common with myeloma. This report describes a rare case of an uncommon condition and highlights the fortunate aspects of this patient's unfortunate diagnosis.

摘要

我们报告一例50岁的西班牙裔男性病例,该患者在右腿间歇性不适3个月后因急性右股骨骨折就诊于急诊科。他最终被诊断为免疫球蛋白D(IgD)多发性骨髓瘤,这是一种罕见的骨髓瘤类型,在诊断时通常处于晚期。幸运的是,我们的患者在诊断时处于I期,且没有骨髓瘤常见的高钙血症、贫血或肾功能不全。本报告描述了一例罕见疾病的罕见病例,并突出了该患者不幸诊断中的幸运之处。

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Early stage IgD multiple myeloma in a 50-year-old man.一名50岁男性的早期IgD型多发性骨髓瘤。
Proc (Bayl Univ Med Cent). 2019 Dec 23;33(2):263-265. doi: 10.1080/08998280.2019.1698878. eCollection 2020 Apr.
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[IgD myeloma manifesting as acute renal insufficiency].
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本文引用的文献

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Presentation Patterns, Diagnostic Markers, Management Strategies, and Outcomes of IgD Multiple Myeloma: A Systematic Review of Literature.IgD型多发性骨髓瘤的临床表现模式、诊断标志物、管理策略及预后:文献系统综述
Cureus. 2019 Feb 4;11(2):e4011. doi: 10.7759/cureus.4011.
2
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.多发性骨髓瘤修订国际分期系统:国际骨髓瘤工作组报告
J Clin Oncol. 2015 Sep 10;33(26):2863-9. doi: 10.1200/JCO.2015.61.2267. Epub 2015 Aug 3.
3
Immunoglobulin D myeloma: clinical features and outcome in the era of novel agents.免疫球蛋白D型骨髓瘤:新型药物时代的临床特征与预后
Eur J Haematol. 2014 Apr;92(4):308-12. doi: 10.1111/ejh.12255. Epub 2014 Jan 26.
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Unusual myelomas: a review of IgD and IgE variants.罕见骨髓瘤:IgD 和 IgE 变异体的综述。
Oncology (Williston Park). 2013 Aug;27(8):798-803.
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Evidence for cytogenetic and fluorescence in situ hybridization risk stratification of newly diagnosed multiple myeloma in the era of novel therapie.新型治疗时代新诊断多发性骨髓瘤的细胞遗传学和荧光原位杂交风险分层的证据。
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Review of 1027 patients with newly diagnosed multiple myeloma.对1027例新诊断的多发性骨髓瘤患者的回顾。
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Immunoglobulin D multiple myeloma: presenting features, response to therapy, and survival in a series of 53 cases.免疫球蛋白D型多发性骨髓瘤:53例病例的临床表现、治疗反应及生存情况
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