Mark J, Ekedahl C, Hagman A
Hum Genet. 1977 May 10;36(3):277-82. doi: 10.1007/BF00446277.
The cytogenetic findings by G-banding in two histiocytic lymphomas are described. Both tumors had a stemline with a 14q+ marker. The origin of the extra segment on No. 14 was determined, and it was different in the two cases. These observations, and those from non-Burkitt lymphomas with 14q+ markers reported in the literature, indicate an inconsistent pattern for the origin of the extra material on No. 14. The only feature in common for all cases is instability of the distal region of the long arm of No. 14, and liability of this region to be involved in structural rearrangements, particularly translocations.
描述了通过G显带对两例组织细胞淋巴瘤进行的细胞遗传学研究结果。两例肿瘤均有一条带有14q+标记的干系。确定了14号染色体上额外片段的来源，两例情况有所不同。这些观察结果以及文献中报道的具有14q+标记的非伯基特淋巴瘤的观察结果表明，14号染色体上额外物质的来源模式并不一致。所有病例唯一的共同特征是14号染色体长臂远端区域的不稳定性，以及该区域易发生结构重排，尤其是易位。
