一例浆细胞白血病中的伯基特型8;14易位。

A Burkitt-type 8;14 translocation in a case of plasma cell leukemia.

作者信息

Yamada K, Shionoya S, Amano M, Imamura Y

出版信息

Cancer Genet Cytogenet. 1983 May;9(1):67-70. doi: 10.1016/0165-4608(83)90026-2.

Abstract

In a 50-year-old patient with plasma cell leukemia, the leukemic cells were found to have a 14q+ marker chromosome derived from the same translocation as that seen in Burkitt's lymphoma, namely, t(8;14)(q24;q32). A 14q+ marker has been reported so far in 13 cases of plasma cell dyscrasia, but only in 3 of them was the origin of the extra material on the 14q+ identified by banding analysis. The present case is the first one shown to involve a 14q+ marker derived from a Burkitt-type 8;14 translocation. Of particular interest is the association of the 8;14 translocation with lymphoid malignancies of the B-cell lineage.

摘要

在一名50岁的浆细胞白血病患者中，发现白血病细胞有一条14q +标记染色体，其来源于与伯基特淋巴瘤中所见相同的易位，即t(8;14)(q24;q32)。迄今为止，在13例浆细胞发育异常病例中报告了14q +标记，但其中只有3例通过显带分析确定了14q +上额外物质的来源。本病例是首例显示涉及源自伯基特型8;14易位的14q +标记的病例。特别令人感兴趣的是8;14易位与B细胞系淋巴恶性肿瘤的关联。