DST Unit of Nanoscience and Thematic Unit of Excellence in Water Research, Department of Chemistry, Indian Institute of Technology, Chennai, Tamil Nadu, 600 036, India.
Chemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu, 641 014, India.
Acta Diabetol. 2020 Oct;57(10):1159-1168. doi: 10.1007/s00592-020-01516-6. Epub 2020 Apr 20.
In last few decades, the prevalence of diabetes and vascular diseases has intensified concurrently with increased use of synthetic chemicals in agriculture. This study is aimed to evaluate the association of co-accumulation of arsenic and organophosphate (OP) insecticides with diabetes and atherosclerosis prevalence in a rural Indian population.
This study included observations from KMCH-NNCD-I (2015) cross-sectional study (n = 865) from an Indian farming village. The participants had assessment of clinical parameters including HbA and carotid intima-media thickness and urinary heavy metals. Serum OP residues were extracted and quantified by GC-MS. Statistical analyses were performed to unravel the co-association of arsenic and OPs on prevalence of diabetes and atherosclerosis.
On multivariate regression analyses, total organophosphate level and arsenic accumulation showed association with diabetes and atherosclerosis. Higher odds ratio with significant trends were observed for the sub-quartiles formed by the combination of higher quartiles of arsenic and total organophosphates in association with diabetes and atherosclerosis.
We observed evidence of possible synergism between arsenic and OPs in association with prevalence of diabetes, pre-diabetes and atherosclerosis in the study population. Our findings highlight the importance of understanding health effects of mixed exposures and raises vital questions on the role of these agrochemicals in the etiology of diabetes and vascular diseases.
在过去几十年中，糖尿病和血管疾病的患病率与农业中合成化学品的使用增加同时加剧。本研究旨在评估砷和有机磷（OP）杀虫剂共同积累与印度农村人口糖尿病和动脉粥样硬化患病率之间的关联。
本研究包括对来自印度一个农业村的 KMCH-NNCD-I（2015 年）横断面研究（n=865）的观察。参与者评估了包括 HbA 和颈动脉内膜中层厚度在内的临床参数，并检测了尿液中的重金属。通过 GC-MS 提取和定量血清 OP 残留。进行统计分析以揭示砷和 OPs 共同对糖尿病和动脉粥样硬化患病率的关联。
在多变量回归分析中，总有机磷水平和砷积累与糖尿病和动脉粥样硬化有关。对于由砷和总有机磷的较高四分位组合形成的子四分位数，观察到与糖尿病和动脉粥样硬化相关的更高比值比和显著趋势。
我们观察到砷和 OPs 之间可能存在协同作用，与研究人群中糖尿病、糖尿病前期和动脉粥样硬化的患病率有关。我们的研究结果强调了了解混合暴露对健康影响的重要性，并提出了关于这些农业化学品在糖尿病和血管疾病病因学中作用的重要问题。
