Trøstrup Hannah, Riis Peter Theut, Heidenheim Michael, Bryld Lars Erik, Jemec Gregor Borut
Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dermatol Ther. 2020 May;33(3):e13432. doi: 10.1111/dth.13432. Epub 2020 Apr 30.
Climatotherapy (CT) is a treatment with immediate high clearance rate for chronic psoriasis, but evidence of long-term effects is scarce. Assessment of the impact of a single CT treatment on disease activity and quality of life was carried out at 4- to 6-month follow-ups. A prospective study of patients with psoriasis undergoing 4 weeks of CT in Israel describes long-term outcomes of CT. Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores were assessed before CT and at an average of 5 months after return. Assessment of the eligibility for CT takes place twice a year. A total of 49 patients (28/21 M/F) participated. Pretreatment PASI was 2.6 to 18.7 (mean 8.1 ± 3.8) vs control PASI 0 to 16.9 (mean 5 ± 2.8), (P < .0001). Mean ΔPASI was 3.2 (39.5% reduction). PASI 75 was achieved by 11/49 patients; 10/49 had increased PASI. The mean DLQI score was 16.1 (range 2-30); 10.6 at follow-up (range 0-28), and 33 patients achieved DLQI minimal clinically important difference (P < .0001). Age, sex, number of previous CT, and duration of observation period did not affect endpoints. CT and unmonitored self-treatment induces PASI 75 in one-fifth patients at follow-up 4 to 6 months later. Six of 10 patients report a clinically important improvement of patients' quality of life as measured by DLQI.
气候疗法（CT）是一种对慢性银屑病具有即时高清除率的治疗方法，但长期疗效的证据却很少。在4至6个月的随访中评估了单次CT治疗对疾病活动和生活质量的影响。一项对以色列接受4周CT治疗的银屑病患者的前瞻性研究描述了CT的长期疗效。在CT治疗前以及返回后平均5个月时评估银屑病面积和严重程度指数（PASI）以及皮肤病生活质量指数（DLQI）得分。CT治疗资格评估每年进行两次。共有49名患者（28名男性/21名女性）参与。治疗前PASI为2.6至18.7（平均8.1±3.8），而对照组PASI为0至16.9（平均5±2.8），（P<0.0001）。平均PASI变化为3.2（降低39.5%）。49名患者中有11名达到PASI 75；49名中有10名PASI升高。平均DLQI得分为16.1（范围2 - 30）；随访时为10.6（范围0 - 28），33名患者达到DLQI最小临床重要差异（P<0.0001）。年龄、性别、既往CT治疗次数和观察期持续时间均不影响终点指标。CT治疗和非监测的自我治疗在4至6个月后的随访中使五分之一的患者达到PASI 75。10名患者中有6名报告称，通过DLQI测量，患者的生活质量有临床上的显著改善。
