Clinical Research Center, Shanghai Skin Diseases Hospital, Medical School of Tongji University, Shanghai, China.
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ann Med. 2023 Dec;55(1):2231847. doi: 10.1080/07853890.2023.2231847.
BACKGROUND: Psoriasis critically influences the psychosocial well-being of patients and reduces their quality of life and work efficiency beyond skin symptoms. However, evidence on the association between life quality based on the Dermatology Life Quality Index (DLQI) and psoriasis severity is limited, particularly in China. This study aimed to explore the association between life quality based on the DLQI evaluation and disease severity among psoriasis patients in China. METHODS: Four thousand two hundred and thirty psoriasis patients were recruited from the Chinese National Clinical Research Center for Skin and Immune Diseases from 2020 to 2021. Information was collected by applying a structured questionnaire and onsite physical examination. Data analysis was performed by using SAS software (version 9.4; SAS Inc., Cary, NC), and statistical significance was set at < .05. RESULTS: Four thousand two hundred and thirty psoriasis patients were predominantly male (64.6%), with a median age of 38.6 years (interquartile range (IQR): 30.0-50.9). The Psoriasis Area and Severity Index (PASI) score for patients with psoriasis was 7.2 (IQR: 3.0-13.5), and 50% of patients with PASI scored over 7. A total of 84.1% of psoriasis patients reported that psoriasis affected their quality of life from mild to severe. The DLQI scores among psoriasis patients were positively correlated with PASI scores ( = 0.43, < .01), both in patients of different sex and different age. Logistic regression analysis with the adjustment of potential confounders indicated that patients with higher PASI score also had higher DLQI score, the odds ratio (OR) were 1.69 (95% confidence interval (CI): 1.38-2.08) for patients with PASI score 3-7, 2.61 (95% CI: 2.10-3.25) for patients with PASI score 8-11 and 3.36 (95% CI: 2.78-4.07) for patients with PASI score ≥12, compared with patients with PASI score <3, respectively. CONCLUSIONS: Life quality based on DLQI evaluation positively correlated with disease severity among patients with psoriasis, especially among male patients and those with higher body mass index. Therefore, we recommend that clinicians treat the DLQI as an important indicator during patient treatment.
背景：银屑病严重影响患者的心理健康，降低生活质量和工作效率，超出皮肤症状的影响。然而，在中国，基于皮肤病生活质量指数（DLQI）评估的生活质量与银屑病严重程度之间的关联证据有限。本研究旨在探讨中国银屑病患者基于 DLQI 评估的生活质量与疾病严重程度之间的关联。
方法：2020 年至 2021 年，从中国国家皮肤与免疫疾病临床医学研究中心招募了 4230 名银屑病患者。通过应用结构化问卷和现场体检收集信息。使用 SAS 软件（版本 9.4；SAS 公司，卡利，NC）进行数据分析，统计显著性设为<0.05。
结果：4230 名银屑病患者主要为男性（64.6%），中位年龄为 38.6 岁（四分位距（IQR）：30.0-50.9）。银屑病患者的银屑病面积和严重程度指数（PASI）评分为 7.2（IQR：3.0-13.5），50%的患者 PASI 评分超过 7。共有 84.1%的银屑病患者报告称，银屑病对他们的生活质量造成了从轻度到重度的影响。银屑病患者的 DLQI 评分与 PASI 评分呈正相关（=0.43，<0.01），无论患者的性别和年龄如何。在调整潜在混杂因素的逻辑回归分析中，PASI 评分较高的患者 DLQI 评分也较高，PASI 评分为 3-7 的患者 OR 为 1.69（95%置信区间（CI）：1.38-2.08），PASI 评分为 8-11 的患者 OR 为 2.61（95%CI：2.10-3.25），PASI 评分为≥12 的患者 OR 为 3.36（95%CI：2.78-4.07），与 PASI 评分<3 的患者相比。
结论：基于 DLQI 评估的生活质量与银屑病患者的疾病严重程度呈正相关，尤其是男性患者和体重指数较高的患者。因此，我们建议临床医生在患者治疗过程中将 DLQI 视为一个重要指标。
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