CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Nanoscale. 2020 May 7;12(17):9517-9523. doi: 10.1039/d0nr01208d.
Owing to the strong NIR absorbance, indocyanine green (ICG) has attracted new attention in emerging photo-theranostics. However, ICG has a very low ROS production efficiency and mainly works through the type II photoreaction via its monomer. The aggregation tendency of ICG in aqueous milieus further worsens the scenario. Herein, ICG aggregates show an enhanced type I photoreaction pathway and have much better photooxidizing capability than its monomer, which improves the performance of ICG in the photodynamic inactivation of bacteria. This finding provides a feasible way to tackle the contradiction of ROS generation and ICG aggregation. Finally, the photodynamic effect of ICG aggregates was combined with the photothermal effect of gold nanorods to achieve an effective treatment of bacterial infection.
由于具有很强的近红外吸收能力，吲哚菁绿（ICG）在新兴的光治疗学中引起了新的关注。然而，ICG 的 ROS 产生效率非常低，主要通过其单体的 II 型光反应起作用。ICG 在水介质中的聚集倾向进一步恶化了这种情况。在此，ICG 聚集体表现出增强的 I 型光反应途径，并且比其单体具有更好的光氧化能力，从而提高了 ICG 在光动力灭活细菌中的性能。这一发现为解决 ROS 产生和 ICG 聚集的矛盾提供了一种可行的方法。最后，将 ICG 聚集体的光动力效应与金纳米棒的光热效应相结合，实现了对细菌感染的有效治疗。
