Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Department of Otorlaryngology, Halkali Merkez Mahallesi, Turgut Özal Bulvarı No. 16, Istanbul 34303, Turkey.
Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Halkali Merkez Mahallesi, Turgut Özal Bulvarı No. 16, Istanbul 34303, Turkey.
Benef Microbes. 2020 May 11;11(3):201-211. doi: 10.3920/BM2019.0119. Epub 2020 Apr 21.
Prevention of acute upper respiratory tract infections (URTIs) is becoming an increasingly important concept in public health application due to the increase in antibiotic resistance. Probiotics have been shown to have some effect on prevention in various reviews. In this study we aimed to re-asses the effect of probiotics as there has been a substantial increase in literature regarding the effects and safety of probiotics in the paediatric population. Two major databases were systematically searched to identify clinical trials eligible for inclusion. Study selection, data extraction and quality assessment were carried out by two reviewers. This review comprises 33 randomised controlled trials (RCTs) applied to a paediatric population with high-quality methodology. The primary outcome for this review was the incidence of respiratory tract infections. Secondary outcomes were severity of symptoms, missed days of school, incidence of antibiotic use and safety of prebiotic use. This review showed that probiotics have an impact on decreasing the incidence of URTIs and the severity of symptoms. The use of probiotics is extremely safe and as studies increase in evaluation of the effect of probiotics more and more show a significant beneficiary effect. Although still a long way from becoming a unanimous treatment modality, the small positive changes that probiotics have on URTIs is important to consider and the use of probiotics should be encouraged more.
由于抗生素耐药性的增加，预防急性上呼吸道感染（URTI）在公共卫生应用中变得越来越重要。益生菌在各种综述中已被证明对预防具有一定作用。在这项研究中，由于有关益生菌在儿科人群中的作用和安全性的文献大量增加，我们旨在重新评估益生菌的作用。我们系统地检索了两个主要数据库，以确定符合纳入标准的临床试验。两名评审员进行了研究选择、数据提取和质量评估。本综述包括 33 项应用于儿科人群的高质量方法学的随机对照试验（RCT）。本综述的主要结局是呼吸道感染的发生率。次要结局是症状严重程度、缺课天数、抗生素使用发生率和使用益生元的安全性。本综述表明益生菌对降低 URTI 的发生率和症状严重程度有影响。益生菌的使用极其安全，随着研究的增加，对益生菌作用的评估越来越多，显示出明显的有益效果。尽管益生菌在成为一种统一的治疗方式方面还有很长的路要走，但益生菌对 URTI 产生的微小积极变化值得考虑，应鼓励更多地使用益生菌。
