PG & Research Department of Chemistry, Thiagarajar College, Madurai 09, Tamil Nadu, India.
Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, ROC.
Ultrason Sonochem. 2020 Sep;66:104977. doi: 10.1016/j.ultsonch.2020.104977. Epub 2020 Jan 18.
The innovation of novel and proficient nanostructured materials for the precise level determination of pharmaceuticals in biological fluids is quite crucial to the researchers. With this in mind, we synthesized iron molybdate nanoplates (Fe(MoO); FeMo NPs) via simple ultrasonic-assisted technique (70 kHz with a power of 100 W). The FeMo NPs were used as the efficient electrocatalyst for electrochemical oxidation of first-generation antihistamine drug- Promethazine hydrochloride (PMH). The as-synthesized FeMo NPs were characterized and confirmed by various characterization techniques such as XRD, Raman, FT-IR, FE-SEM, EDX and Elemental mapping analysis and electron impedance spectroscopy (EIS). In addition, the electrochemical characteristic features of FeMo NPs were scrutinized by electrochemical techniques like cyclic voltammetry (CV) and differential pulse voltammetry technique (DPV). Interestingly, the developed FeMo NPs modified glassy carbon electrode (FeMo NPs/GCE) discloses higher peak current with lesser anodic potential on comparing to bare GCE including wider linear range (0.01-68.65 µM), lower detection limit (0.01 µM) and greater sensitivity (0.97 µAµMcm). Moreover, the as-synthesized FeMo NPs applied for selectivity, reproducibility, repeatability and storage ability to investigate the practical viability. In the presence of interfering species like cationic, anionic and biological samples, the oxidation peak current response doesn't cause any variation results disclose good selectivity towards the detection of PMH. Additionally, the practical feasibility of the FeMo NPs/GCE was tested by real samples like, commercial tablet (Phenergan 25 mg Tablets) and lake water samples which give satisfactory recovery results. All the above consequences made clear that the proposed sensor FeMo NPs/GCE exhibits excellent electrochemical behavior for electrochemical determination towards oxidation of antihistamine drug PMH.
对于研究人员来说，创新新型且熟练的纳米结构材料，以精确测定生物流体中的药物水平至关重要。考虑到这一点，我们通过简单的超声辅助技术（70 kHz，功率为 100 W）合成了钼酸亚铁纳米板（Fe（MoO）4；FeMo NPs）。FeMo NPs 被用作第一代抗组胺药-盐酸异丙嗪（PMH）电化学氧化的有效电催化剂。通过各种表征技术，如 XRD、拉曼、FT-IR、FE-SEM、EDX 和元素映射分析以及电子阻抗谱（EIS），对合成的 FeMo NPs 进行了表征和确认。此外，通过电化学技术，如循环伏安法（CV）和差分脉冲伏安法（DPV），研究了 FeMo NPs 的电化学特性。有趣的是，与裸 GCE 相比，开发的 FeMo NPs 修饰玻碳电极（FeMo NPs/GCE）显示出更高的峰电流和更小的阳极电位，包括更宽的线性范围（0.01-68.65 µM）、更低的检测限（0.01 µM）和更高的灵敏度（0.97 µAµMcm）。此外，还研究了合成的 FeMo NPs 的选择性、重现性、重复性和存储能力，以考察其实际可行性。在存在阳离子、阴离子和生物样品等干扰物质的情况下，氧化峰电流响应没有发生任何变化，结果表明对 PMH 的检测具有良好的选择性。此外，通过实际样品，如市售片剂（Phenergan 25 mg 片剂）和湖水样品，测试了 FeMo NPs/GCE 的实际可行性，结果令人满意。所有这些结果都清楚地表明，所提出的传感器 FeMo NPs/GCE 对用于 PMH 氧化的电化学测定具有优异的电化学行为。
