State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China; Department of Operative Dentistry and Endodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China; National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610064, China.
Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Oral Oncol. 2020 Jul;106:104723. doi: 10.1016/j.oraloncology.2020.104723. Epub 2020 Apr 18.
In head and neck squamous cell carcinoma (HNSCC), tumor-associated macrophages (TAMs) are associated with a poorer prognosis. TAMs, derived from inflammatory monocyte, play a critical role in regulating tumor progression. Generally, TAMs promote tumor progression and suppress immune response via both innate and adaptive immune mechanisms. However, as the double-blade sword, TAMs retain the potential pro-inflammatory ability to inhibit tumor progression. By depleting the immunosuppressive function or evoking anti-tumor ability, therapeutic strategies targeting TAMs show promising preclinical and clinical effects. Now, macrophage-centered therapeutic approaches are entering the clinical arena. In this review, we discuss the immunosuppressive role of TAMs in the tumor microenvironment and the therapeutic approaches targeting macrophages which offer promise in improving HNSCC outcome.
在头颈部鳞状细胞癌（HNSCC）中，肿瘤相关巨噬细胞（TAMs）与预后较差相关。TAMs 来源于炎症性单核细胞，在调节肿瘤进展中发挥关键作用。通常，TAMs 通过先天和适应性免疫机制促进肿瘤进展并抑制免疫反应。然而，作为双刃剑，TAMs 保留了抑制肿瘤进展的潜在促炎能力。通过耗尽抑制性免疫功能或引发抗肿瘤能力，靶向 TAMs 的治疗策略显示出有前途的临床前和临床效果。现在，以巨噬细胞为中心的治疗方法正在进入临床领域。在这篇综述中，我们讨论了 TAMs 在肿瘤微环境中的免疫抑制作用，以及靶向巨噬细胞的治疗方法在改善 HNSCC 结局方面的潜力。
