p53与FBXW7：有时两位守护者比一位更糟糕。
p53 and FBXW7: Sometimes Two Guardians Are Worse than One.
作者信息
Galindo-Moreno María, Giráldez Servando, Limón-Mortés M Cristina, Belmonte-Fernández Alejandro, Sáez Carmen, Japón Miguel Á, Tortolero Maria, Romero Francisco
机构信息
Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, E-41012 Sevilla, Spain.
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, E-41013 Sevilla, Spain.
出版信息
Cancers (Basel). 2020 Apr 16;12(4):985. doi: 10.3390/cancers12040985.
Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of FBXW7 in the degradation of p53 and the possible implications of this finding in tumor cell development. We also speculate about the function of FBXW7 as a key player in the cell fate after DNA damage and how this could be exploited in the treatment of cancer disease.
过犹不及。一个例子是FBXW7，一种著名的肿瘤抑制因子，它也可能促进肿瘤发生。在此，我们思考了三个实验室关于FBXW7在p53降解中的作用的研究结果，以及这一发现对肿瘤细胞发育可能产生的影响。我们还推测了FBXW7作为DNA损伤后细胞命运的关键参与者的功能，以及如何在癌症治疗中加以利用。
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