Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida, USA.
Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
High Alt Med Biol. 2020 Sep;21(3):232-236. doi: 10.1089/ham.2019.0109. Epub 2020 Apr 21.
Hennigar, Stephen R., Claire E. Berryman, Alyssa M. Kelley, Bradley J. Anderson, Andrew J. Young, James P. McClung, and Stefan M. Pasiakos. High-altitude acclimatization suppresses hepcidin expression during severe energy deficit. . 21:232-236, 2020. The erythropoietic cells in the bone marrow require iron to synthesize heme for incorporation into hemoglobin. Exposure to hypoxic conditions, such as extended sojourns to high altitude (HA), results in increased erythropoiesis and an increased physiological requirement for iron. In addition to increasing iron requirements, hypoxic conditions suppress appetite and often lead to decreased energy intake. The objective of this study was to determine the combined effects of severe energy deficit and hypoxia on hepcidin and measures of iron status in lowlanders sojourning to HA. Iron status indicators and hepcidin were determined in 17 healthy male volunteers (mean ± standard deviation, age 23 ± 6 years, body mass index 27 ± 4 kg/m) fed a controlled diet (12 ± 1.2 mg iron/day) during a 20-day sojourn to 4300 m above sea level. Chronic exposure to HA during severe energy deficit increased hematocrit by 12% ( < 0.01) and decreased serum hepcidin by 37% ( < 0.01) compared with baseline. Ferritin declined by 18% ( = 0.02) and transferrin saturation and soluble transferrin receptor increased by 55% and 83%, respectively ( < 0.01 for both) compared with baseline. HA acclimatization suppresses hepcidin expression to increase iron availability during severe energy deficit. Registered at ClinicalTrials.gov as NCT02731066.
亨尼格（Hennigar），斯蒂芬·R（Stephen R.），克莱尔·E·贝里曼（Claire E. Berryman），艾莉莎·M·凯利（Alyssa M. Kelley），布拉德利·J·安德森（Bradley J. Anderson），安德鲁·J·杨（Andrew J. Young），詹姆斯·P·麦克卢恩（James P. McClung）和斯特凡·M·帕西亚科斯（Stefan M. Pasiakos）。高海拔适应抑制严重能量不足时的铁调素表达。《生理学前沿》21:232-236，2020 年。骨髓中的红细胞生成细胞需要铁来合成血红素以掺入血红蛋白中。暴露于低氧条件（例如，长时间停留于高海拔地区）会导致红细胞生成增加和铁的生理需求增加。除了增加铁的需求外，低氧条件还会抑制食欲，常常导致能量摄入减少。本研究的目的是确定严重能量不足和低氧对移居到高海拔地区的低地居民的铁调素和铁状态指标的综合影响。17 名健康男性志愿者（平均年龄 23 ± 6 岁，体重指数 27 ± 4kg/m2）在海拔 4300 米以上的地方停留 20 天时，根据饮食控制（每天 12 ± 1.2mg 铁）来确定铁状态指标和铁调素。与基线相比，慢性暴露于高海拔地区时严重能量不足使红细胞比容增加 12%（ <0.01），使血清铁调素减少 37%（ <0.01）。与基线相比，铁蛋白下降 18%（ =0.02），转铁蛋白饱和度和可溶性转铁蛋白受体分别增加 55%和 83%（均 <0.01）。高海拔适应抑制铁调素的表达，以增加严重能量不足时铁的可利用性。在 ClinicalTrials.gov 上注册为 NCT02731066。
