Bergman S M, Lyman D J, Middleton R G
Invest Urol. 1977 May;14(6):411-6.
Free floating segments of block copolyurethane were implanted into rat bladders and compared with similar implants of silicone rubber. This urethane was far superior to silicone rubber in its ability to withstand incrustation in the rat bladder. Ten dogs had a segment of right ureter replaced by a tubular segment of smooth (or film) urethane and were followed with intravenous urography. At 1 month, eight of 10 dogs had right hydronephrosis. At the time of sacrifice (4 or 8 months) seven dogs had reduced hydronephrosis, and in three dogs intravenous urography was unsatisfactory for grading. Only two of the ten dogs had significant urinary infection. A smooth protein-like coasting appeared along the lumen of the graft, incrustation was minimal, and new mucosa and smooth muscle regeneration was seen. This material was well tolerated in the urinary tracts of dogs and rats.
将嵌段共聚聚氨酯的游离片段植入大鼠膀胱，并与硅橡胶的类似植入物进行比较。这种聚氨酯在抵抗大鼠膀胱结石形成的能力方面远优于硅橡胶。十只狗的右侧输尿管的一段被光滑（或薄膜）聚氨酯的管状段所替代，并通过静脉尿路造影进行随访。1个月时，10只狗中有8只出现右侧肾积水。在处死时（4或8个月），7只狗的肾积水减轻，3只狗的静脉尿路造影结果无法进行分级。10只狗中只有2只有明显的泌尿系统感染。移植物管腔内出现了一层光滑的蛋白质样涂层，结石形成极少，并且可见新的黏膜和平滑肌再生。这种材料在狗和大鼠的尿路中耐受性良好。
