Kim Alexander Y, Yacoub Joseph H, Field David H, Park Byoung Uk, Kallakury Bhaskar, Korolowicz Kyle E, Menne Stephan
Department of Radiology Medstar Georgetown University Hospital Washington District of Columbia.
Department of Pathology and Laboratory Medicine Medstar Georgetown University Hospital Washington District of Columbia.
Animal Model Exp Med. 2020 Feb 9;3(1):98-102. doi: 10.1002/ame2.12100. eCollection 2020 Mar.
The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies. We describe the techniques for pre-embolization imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.
最常用的肝细胞癌（HCC）临床前模型在用于测试诸如经动脉化疗栓塞和放射性栓塞等动脉内治疗方面存在局限性。更常用的动物模型所面临的问题包括与人类相比其疾病发展的差异以及脉管系统的大小，这可能使动脉内治疗测试变得困难或无法进行。在此，我们描述土拨鼠HCC模型在测试动脉内治疗方面的适用性。我们描述了使用CT和MRI进行栓塞前成像评估的技术、进行血管造影和栓塞的技术要点以及治疗后肝脏的病理评估。
