Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Chem Commun (Camb). 2020 May 28;56(43):5771-5774. doi: 10.1039/d0cc02039g.
An ambident electrophilicity of phosphinic acid thioesters is disclosed. Unexpected carbon-sulfur bond formation took place in the reaction between phosphinic acid thioesters and benzyl Grignard reagents. The developed method for benzyl sulfides has a wide substrate scope and was applicable for the synthesis of a drug analog.
公开了膦酸硫酯的双反应性亲电性。在膦酸硫酯与苄基格氏试剂的反应中发生了意想不到的碳-硫键形成。开发的苄基硫化物方法具有广泛的底物范围，可用于合成药物类似物。
