无催化剂和添加剂的条件下，使用 DMSO 作为溶剂和氧化剂，实现了元素硫对咪唑杂环的双 C-H 硫醚化反应。
Catalyst and additive-free oxidative dual C-H sulfenylation of imidazoheterocycles with elemental sulfur using DMSO as a solvent and an oxidant.
机构信息
School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China.
Department of Pharmacy, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450001, P. R. China.
出版信息
Chem Commun (Camb). 2020 May 28;56(43):5751-5754. doi: 10.1039/d0cc00043d.
PMID:32319979
Abstract
Dual C-H sulfenylation was used to obtain 3-vulcanized imidazoheterocycles using odorless elemental sulfur under catalyst- and additive-free conditions. C-H activation of both imidazoheterocycles and arylamines/arenols/indoles was realized by a practical protocol in which DMSO served as both a solvent and an internal oxidant.
摘要
双 C-H 硫化反应在无催化剂和添加剂的条件下，使用无味的元素硫，得到 3 个硫化的咪唑杂环化合物。通过一个实际的方案，实现了咪唑杂环化合物和芳胺/芳醇/吲哚的 C-H 活化，其中 DMSO 既是溶剂又是内部氧化剂。
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