Department of Neuropsychiatry, Universidade Federal de Pernambuco (UFPE), Recife, Brazil.
Headache Clinic, Hospital Universitario Oswaldo Cruz, Universidade de Pernambuco (UPE), Recife, Brazil.
Headache. 2020 May;60(5):967-973. doi: 10.1111/head.13815. Epub 2020 Apr 22.
This study evaluated headaches among Parkinson's disease (PD) patients and whether there was any correlation between the motor symptoms and the severity of the headaches presented.
Forty to 83% of PD patients are affected by pain. Despite this high prevalence of pain, only a few studies have addressed the headaches of these patients.
This was a cross-sectional study. Consecutive patients with Parkinson disease were included. Semi-structured interview; the Epworth sleepiness scale; the Hospital Anxiety and Depression Scale; the Unified Parkinson's Disease Rating Scale (UPDRS), Part III (motor examination); and the Hoehn and Yahr scale were used.
About 46 patients were included, 52% were men, mean age was 66 ± 11 years. Forty-three patients had headaches, 12/46 (26%), migraines, 31/46 (67%) had tension-type headaches. We found no association between the headache frequency (median: 0.5; 0.5 to 7.5 vs 0.5; 0.5 to 8 days/3 months; P = .757) or intensity (median: 5; 4 to 8 vs 5.5, 4 to 9; P = .514) and the different stages of the PD (Hoehn and Yahr scale: ≤2.5 vs >2.5). There was no correlation between UPDRS score and the intensity (r = -0.099; P = .530) or frequency of headaches (r = -0.136; P = .373). No association was found between the grade of neck stiffness (0 vs 1 and 2 vs 3 and 4) and the headache frequency (Median: 0; 0 to 3 vs 3.5; 0 to 12.5 vs 0; 0 to 6 days/3 months; P = .074) or intensity (Median: 5; 3 to 9 vs 5; 4 to 6 vs 7; 4.5 to 9; P = .434). Twelve patients said that their headaches started after PD had been diagnosed. There was no difference regarding the frequency and characteristics of headaches and PD characteristics between these patients and the other patients with previous headaches.
In this sample of PD patients, there is no association between headache and PD.
本研究评估了帕金森病（PD）患者的头痛情况，以及运动症状与头痛严重程度之间是否存在任何相关性。
40%至 83%的 PD 患者受到疼痛的影响。尽管疼痛的患病率如此之高，但只有少数研究涉及这些患者的头痛。
这是一项横断面研究。纳入了连续的帕金森病患者。采用半结构式访谈；Epworth 嗜睡量表；医院焦虑和抑郁量表；帕金森病评定量表（UPDRS）第三部分（运动检查）；和 Hoehn 和 Yahr 量表。
共纳入了约 46 名患者，其中 52%为男性，平均年龄为 66±11 岁。43 名患者有头痛，其中 12/46（26%）为偏头痛，31/46（67%）为紧张型头痛。我们未发现头痛频率（中位数：0.5；0.5 至 7.5 与 0.5；0.5 至 8 天/3 个月；P=0.757）或强度（中位数：5；4 至 8 与 5.5，4 至 9；P=0.514）与 PD 的不同阶段（Hoehn 和 Yahr 量表：≤2.5 与>2.5）之间存在关联。UPDRS 评分与头痛强度（r=-0.099；P=0.530）或频率（r=-0.136；P=0.373）之间也没有相关性。颈部僵硬程度（0 与 1 和 2 与 3 和 4）与头痛频率（中位数：0；0 至 3 与 3.5；0 至 12.5 与 0；0 至 6 天/3 个月；P=0.074）或强度（中位数：5；3 至 9 与 5；4 至 6 与 7；4.5 至 9；P=0.434）之间也没有相关性。12 名患者表示他们的头痛是在 PD 确诊后开始的。这些患者与其他有先前头痛的患者在头痛的频率和特征以及 PD 特征方面没有差异。
在本 PD 患者样本中，头痛与 PD 之间没有关联。
