Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Rev Soc Bras Med Trop. 2020 Apr 22;53:e20190443. doi: 10.1590/0037-8682-0443-2019. eCollection 2020.
Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients.
We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs.
ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs.
Close follow-up is warranted for CD patients.
本研究旨在确定慢性恰加斯病（CD）患者发生药物不良事件（ADEs）的相关因素。
我们分析了 295 名患者的 320 份病历。应用 Naranjo 算法确定 ADEs 的原因。采用混合效应逻辑回归评估与 ADEs 相关的因素。
102 份病历（31.9%）描述了 ADEs。卡托普利与 ADEs 最相关。年龄（RR 0.96；95%CI 0.94-0.99）和心脏 C/D 期（RR 3.24；95%CI 1.30-4.58）是与 ADEs 最相关的重要临床因素。
需要对 CD 患者进行密切随访。
