Vasculocardiology Department, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
Clinics (Sao Paulo). 2020 Apr 17;75:e1450. doi: 10.6061/clinics/2020/e1450. eCollection 2020.
Systemic lupus erythematosus (SLE) is a chronic systematic autoimmune disease. Current methods of diagnosing SLE or evaluating its activity are complex and expensive. Numerous studies have suggested that neutrophil-to-lymphocyte ratio (NLR) is closely correlated with the presence of SLE and its activity, suggesting that it may serve as a diagnostic and monitoring indicator for SLE. Therefore, we performed a meta-analysis to systematically assess the association between NLR and SLE. We performed a literature search until 12 April 2019 in the PubMed, Web of Science, and China National Knowledge Infrastructure databases. Cross-sectional studies comparing the NLR of SLE patients versus those of healthy controls, of active versus inactive SLE patients, and of SLE patients with versus without lupus nephritis were considered for inclusion. Mean intergroup NLR differences were estimated using standardized mean differences and their 95% confidence intervals. Study quality was assessed using the Agency for Healthcare Research and Quality instrument for cross-sectional studies. Fourteen studies with 1,781 SLE patients and 1,330 healthy controls were included in this meta-analysis. The pooled results showed that the NLR was significantly higher in SLE patients than in healthy controls, in active SLE patients than in inactive SLE patients, and in SLE patients with lupus nephritis than in those without lupus nephritis. NLR may be an indicator for monitoring disease activity and reflecting renal involvement in SLE patients. Nevertheless, more high-quality studies are warranted to further validate our findings.
系统性红斑狼疮（SLE）是一种慢性系统性自身免疫性疾病。目前诊断 SLE 或评估其活动的方法复杂且昂贵。许多研究表明，中性粒细胞与淋巴细胞比值（NLR）与 SLE 的存在及其活动密切相关，表明它可能作为 SLE 的诊断和监测指标。因此，我们进行了一项荟萃分析，以系统评估 NLR 与 SLE 之间的相关性。我们在 PubMed、Web of Science 和中国国家知识基础设施数据库中进行了文献检索，检索时间截至 2019 年 4 月 12 日。纳入比较 SLE 患者与健康对照者、活动期与非活动期 SLE 患者、伴狼疮肾炎与不伴狼疮肾炎 SLE 患者 NLR 的横断面研究。使用标准化均数差及其 95%置信区间估计组间 NLR 差异。使用横断面研究的医疗保健研究与质量机构工具评估研究质量。这项荟萃分析纳入了 14 项研究，共 1781 例 SLE 患者和 1330 例健康对照者。汇总结果显示，SLE 患者的 NLR 明显高于健康对照者，活动期 SLE 患者的 NLR 明显高于非活动期 SLE 患者，伴狼疮肾炎的 SLE 患者的 NLR 明显高于不伴狼疮肾炎的 SLE 患者。NLR 可能是监测疾病活动度和反映 SLE 患者肾脏受累的指标。然而，需要更多高质量的研究来进一步验证我们的发现。
