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在埃塞俄比亚西南部的 Mizan Tepi 大学教学医院和 Tepi 综合医院接受随访的 HIV 阳性孕妇中,抗逆转录病毒治疗的依从性。

Adherence to Antiretroviral Therapy Among HIV-Positive Pregnant Women on followup at Mizan Tepi University Teaching and Tepi General Hospitals, Southwest Ethiopia.

机构信息

Mizan Tepi University, Mizan Teferi, Ethiopia.

Nyinenyang Hospital, Gambela Region, Gambela, Ethiopia.

出版信息

J Prim Care Community Health. 2020 Jan-Dec;11:2150132720902561. doi: 10.1177/2150132720902561.

DOI:10.1177/2150132720902561
PMID:32321354
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7180300/
Abstract

The introduction of highly active antiretroviral therapy has not only improved longevity in human immunodeficiency virus (HIV)-infected individuals but in addition has had a significant impact on the rate of mother-to-child transmission of the infection. To assess antiretroviral therapy adherence among HIV-positive pregnant women on follow-up at antiretroviral therapy clinic of Mizan Tepi University Teaching and Tepi General Hospitals. A descriptive cross-sectional study was undertaken in antiretroviral therapy clinics of Mizan Tepi University Teaching and Tepi General Hospitals from April to May 2018. Data were collected through face to face interview using structured and pretested questionnaires and analyzed using Statistical Package for Social Sciences version 20. Majority of the patients had good adherence to their antiretroviral therapy, 68 (66.00%). Medication side effects, 12 (34.00%) and forgetfulness and distance of the hospital from home, each accounting 11 (31.00%) were the main reasons for nonadherence among nonadherent patients. Frequency of counseling ( = .000), CD4 count (χ = 37.529, = .000), World Health Organization's clinical stage (χ = 17.515, = .000), stigma (χ = 70.426, = .000), and family support (χ = 46.383, = .000) were found to be associated with patients' medication adherence. The overall patient adherence to antiretroviral therapy in the study facilities was good. Collaborative work among patients, health care organizations, and the public are necessary to tackle the adherence obstacles and enhance patient adherence to the prescribed medication.

摘要

高效抗逆转录病毒疗法的引入不仅提高了感染人类免疫缺陷病毒(HIV)个体的寿命,而且还显著降低了母婴传播感染的比率。本研究旨在评估米赞提皮大学教学医院和提皮综合医院抗逆转录病毒治疗门诊中 HIV 阳性孕妇的抗逆转录病毒治疗依从性。这是一项在 2018 年 4 月至 5 月期间在米赞提皮大学教学医院和提皮综合医院抗逆转录病毒治疗门诊进行的描述性横断面研究。通过面对面访谈,使用结构化和预测试问卷收集数据,并使用社会科学统计软件包 20 版进行分析。大多数患者对抗逆转录病毒治疗的依从性良好,有 68 例(66.00%)。药物副作用(34.00%)和健忘以及医院离家远(各占 31.00%)是不依从患者未坚持服药的主要原因。咨询频率( =.000)、CD4 计数( = 37.529, =.000)、世界卫生组织临床分期( = 17.515, =.000)、耻辱感( = 70.426, =.000)和家庭支持( = 46.383, =.000)与患者的药物依从性相关。研究机构中,总体上患者对抗逆转录病毒治疗的依从性良好。需要患者、医疗机构和公众之间的协作,以解决依从性障碍,提高患者对处方药物的依从性。

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