Ebuy Haftamu, Yebyo Henock, Alemayehu Mussie
Dr. Tewelde Legesse College of Health Sciences, PO Box 106, Mekelle, Ethiopia.
Department of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
Int J Infect Dis. 2015 Apr;33:123-9. doi: 10.1016/j.ijid.2014.12.026. Epub 2014 Dec 18.
The aim of this study was to determine the level of adherence to Option B+ PMTCT drugs and factors associated with adherence among HIV-positive pregnant women in public hospitals of Tigray, northern Ethiopia.
A cross-sectional study was conducted among 277 HIV-positive pregnant women in 2014. A two-stage cluster sampling technique was used to select the study participants. Individual consent was obtained from each participant. Multivariate logistic regression was used to estimate the net effect sizes of factors associated with adherence to Option B+ PMTCT drugs.
The level of adherence of respondents to Option B+ PMTCT drugs was 87.1% (95% confidence interval (CI) 82.6-90.7%). Controlling for the effect of other factors, the odds of adhering to Option B+ PMTCT were 4.7 times higher among women who received counselling on medication as compared to those who did not (adjusted odds ratio (aOR) 4.7, 95% CI 1.98-11.35). Similarly, disclosing HIV status was positively associated with good adherence (aOR 4.2, 95% CI 1.07-16.33).
The adherence level was found to be reasonably good. Counselling on medication and HIV status disclosure were positive predictors of adherence to Option B+ PMTCT drugs.
本研究旨在确定埃塞俄比亚北部提格雷地区公立医院中感染艾滋病毒的孕妇对B+预防母婴传播方案药物的依从性水平以及与依从性相关的因素。
2014年对277名感染艾滋病毒的孕妇进行了一项横断面研究。采用两阶段整群抽样技术选择研究参与者。从每位参与者处获得个人同意。使用多变量逻辑回归来估计与B+预防母婴传播方案药物依从性相关因素的净效应大小。
受访者对B+预防母婴传播方案药物的依从性水平为87.1%（95%置信区间（CI）82.6 - 90.7%）。在控制其他因素的影响后，接受药物咨询的女性坚持B+预防母婴传播方案的几率是未接受咨询女性的4.7倍（调整后的优势比（aOR）4.7，95% CI 1.98 - 11.35）。同样，披露艾滋病毒感染状况与良好的依从性呈正相关（aOR 4.2，95% CI 1.07 - 16.33）。
发现依从性水平相当不错。药物咨询和艾滋病毒感染状况披露是坚持B+预防母婴传播方案药物的积极预测因素。
