Effects of Germline Mutations on Triple-Negative Breast Cancer Prognosis.

Germline and mutations confer an increased lifetime risk for breast cancer and ovarian cancer. Several studies have investigated prognosis among mutation carriers and noncarriers, but the prognostic impact on outcomes of breast cancer patients has not been determined. The aim of this study was to determine the prognosis of TNBC patients with and without germline mutation. Among 502 patients diagnosed with TNBC between 2005 and 2008, 124 patients with a strong family history of breast cancer or ovarian cancer as well as TNBC patients diagnosed under 45 years were referred to the Genetic Counseling Unit for genetic counselling and genetic tests. In 30 (24%) of them, the mutation was detected (the most common 5382insC in 18 (60%) patients). The median follow-up of the entire group was 60 months. mutation carriers were statistically significantly younger at TNBC diagnosis compared with nonmutation patients (41 vs 47 years, respectively). Patients with the mutation had smaller tumors (stage I: 47% vs 24.5% in noncarriers), but there was no significant difference in the regional nodal status (58.5-63% with cN0). Contralateral breast cancer developed in 26.5% of mutation carriers and in 14% of noncarriers. Other primary cancers were also slightly more common in mutation carriers (16.5% vs 9.5%). The performed analysis did not show any significant differences between the groups in recurrence-free survival (=0.312). There was no significant difference between patients with or without mutation as regards overall survival (=0.649) and the risk of TNBC death (=0.333). The survival from detection of metastases was similar in two groups (=0.865). Our study demonstrated that the mutation does not affect TNBC patients' outcomes.